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KMID : 0374019900130030139
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Ewha Medical Journal
1990 Volume.13 No. 3 p.139 ~ p.148
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Study on the Efficacy of the Experimentally Prepared Nitroxynil-Levamisole Compound Injection Against Liver Fluke and Gastrointestinal Roundworms in Ruminants
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Abstract
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The present study was carried out to evaluate the efficacy of the experimentally prepared injection of nitroxynil-levamisole a
a gainst liver fluke and gastrointestinal roundworms in goats
and cattle. For the purpose, the dose confirmation trial, the dose reduction trial and clinical
i field trial were conducted according to "the guidelines for evaluating the efficacy of anthelmintics in ruminants" approved by the General ´Meeting of the 9th International Conference of the World Association forthe .Advancement of Veterinary Parasitology" in 1981.
The results obtained are summarized as follows
1) A single dose of _10mg/kg of nitroxynil injection alone against the liver fluke and that of 5.Omglkg of levamisole injection alone against gastrointestinal roundworms in goats were highly effective in the cure rate and the egg reduction rate, respectively.
f 2) A single dose of the experimentally prepared compound injection at the dose levels
of nitroxynil 10.Omg-12.Omg/kg and levamisole 5.Omg-6.Omg/kg was highly effective in the egg reduction rates of both liver fluke(98.4 % -100 % ) and gastrointestinal roundworms(97.3 % - 98A % ) without any side reaction in goats.
3) A single dose of the experimentally prepared compound injection at the reduced dose level of nitroxynil 7.5mg/kg and levamisole 5.Omg/kg was highly effective in the egg reduction rates of both liver fluke and gastrointestinal roundworms in goats.
4) In the clinical field trial, a single dose of the experimentally prepared compound injection at the reduced dose level of nitroxynil 7.5mg/kg and levamisole 5.Omg/kg showed also very high efficacy in the cure rates and the egg reduction rates of both liver fluke and gastrointestinal roundworms in Korean cattle, dairy cow and beef cattle. However, it was not effective against Ostertagia sp, among gastrointestinal roundworms. No side reactions were noted.
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